Progesterone Cream – 30 Grams (Topical Bioidentical Hormone Therapy)

(Compounded 30 Gram Cream for Menopausal, Perimenopausal, and Hormonal Support)

Bioidentical Hormone Support for Balance, Relief, and Wellness

Progesterone Cream – 30 grams is a custom-compounded, bioidentical hormone therapy (BHT) formulation designed to support hormonal balance, particularly in women experiencing perimenopause, menopause, or luteal phase dysfunction. Applied topically, this cream delivers micronized USP progesterone through the skin for systemic absorption, bypassing gastrointestinal metabolism and reducing the need for oral administration.

This 30-gram formulation is prepared in a non-irritating, hypoallergenic base and may be customized in strength as prescribed by a healthcare provider—commonly ranging from 20–100 mg of progesterone per gram. It is intended to mimic the body’s natural progesterone and is often used as part of individualized hormone replacement therapy (HRT) programs.

Key Benefits

  • Provides micronized USP-grade bioidentical progesterone

  • Designed for transdermal absorption—no need for oral pills

  • Helps relieve menopausal and perimenopausal symptoms

  • Supports estrogen balance, reducing risk of estrogen dominance

  • May improve mood, sleep, menstrual regulation, and skin elasticity

  • Compounded in a customizable strength per prescription

  • Packaged in a 30-gram metered pump or jar for accurate dosing

  • Formulated in a non-comedogenic, paraben-free cream base

What Is Progesterone?

Progesterone is a key hormone in the female endocrine system, produced primarily by the ovaries after ovulation. It plays a central role in:

  • Regulating menstrual cycles

  • Supporting fertility and early pregnancy

  • Balancing estrogen levels to prevent estrogen dominance

  • Influencing mood, cognition, and stress response

  • Supporting bone, breast, and cardiovascular health

As women approach perimenopause and menopause, progesterone production declines earlier and more abruptly than estrogen, leading to hormonal imbalances that may cause symptoms such as:

  • Hot flashes and night sweats

  • Mood swings, anxiety, or irritability

  • Irregular or heavy periods

  • Sleep disturbances

  • Breast tenderness or bloating

Topical progesterone cream offers a convenient and effective way to restore hormonal equilibrium and improve quality of life.

Clinical Applications

This compounded progesterone cream is typically prescribed for:

1. Perimenopause and Menopause

  • Reduces hot flashes, night sweats, and vaginal dryness

  • Improves mood, libido, and sleep quality

2. Estrogen Dominance

  • Counteracts unopposed estrogen in HRT regimens

  • Alleviates symptoms such as breast tenderness, bloating, and irritability

3. Irregular or Heavy Menstrual Cycles

  • Stabilizes luteal phase and supports cycle regularity

4. Premenstrual Syndrome (PMS) or PMDD

  • Eases emotional and physical symptoms linked to hormonal fluctuations

5. Fertility and Reproductive Support (under OB-GYN supervision)

  • May be used to support implantation and luteal phase health

Application & Dosing

  • Applied once or twice daily to thin-skinned areas (e.g., inner arms, thighs, abdomen)

  • Common dosages range from 20–100 mg per day, depending on need

  • Should be rotated between application sites

  • Use exact dosing instructions provided by the prescribing physician

  • Absorption typically begins within minutes, with steady-state achieved in 3–5 days

Safety and Monitoring

While bioidentical progesterone is generally well tolerated, monitoring by a healthcare provider is important—especially in hormone-sensitive patients. Possible side effects include:

  • Breast tenderness or mild fluid retention

  • Fatigue or drowsiness (typically dose-dependent)

  • Spotting or cycle changes during adjustment phase

These effects often resolve as hormone levels stabilize. Dosage adjustments may be made based on saliva, blood, or symptom-based monitoring.

Contraindications

  • Known hypersensitivity to progesterone or cream base ingredients

  • Undiagnosed vaginal bleeding

  • History of hormone-sensitive cancers (e.g., breast or endometrial)

  • Use with caution in patients with liver dysfunction, depression, or thromboembolic disorders

Storage & Handling

  • Store at controlled room temperature: 15–25°C (59–77°F)

  • Keep container tightly closed and away from direct sunlight

  • Do not freeze

  • For external use only; keep out of reach of children

Ideal For

  • Women navigating perimenopause or menopause symptoms

  • Patients using estrogen therapy needing a balancing progesterone

  • Individuals seeking natural hormone replacement options

  • Clinicians practicing functional, naturopathic, or integrative medicine

Progesterone Cream – 30 Grams offers a customizable, transdermal solution for addressing hormonal imbalances with precision and convenience. It reflects a modern, patient-centered approach to hormonal wellness—backed by clinical relevance, compounding accuracy, and personalized care.

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