(Bioidentical Estrogen Therapy for Vaginal Atrophy, GSM, and Menopausal Support)
Gentle, Targeted Hormone Support for Vaginal and Urogenital Health
Estriol 30 gm Cream is a bioidentical, low-potency estrogen therapy specially compounded for topical or vaginal application. It is used to address the symptoms of genitourinary syndrome of menopause (GSM), including vaginal dryness, irritation, thinning of mucosa, and pain during intercourse (dyspareunia). Estriol is considered the mildest form of estrogen, making it ideal for women seeking localized hormone support with minimal systemic absorption.
Unlike estradiol or conjugated estrogens, estriol has a lower binding affinity for estrogen receptors, which reduces the risk of estrogen-related side effects while still offering effective relief from atrophic and inflammatory symptoms.
This 30-gram size is ideal for monthly use and ensures accurate dosing and ease of application, typically dispensed in a metered-dose syringe or airless pump.
Key Benefits
- Contains bioidentical estriol – the gentlest natural estrogen
- Promotes mucosal regeneration, moisture retention, and collagen support
- Relieves vaginal dryness, itching, burning, and postmenopausal discomfort
- Supports urogenital tissue elasticity and pH balance
- Ideal for perimenopausal, menopausal, or postpartum hormone decline
- Minimally systemic – safe for localized therapy under physician supervision
- Compounded in a USP <795>/<797>-compliant facility
What Is Estriol?
Estriol is one of the three primary forms of estrogen produced by the female body (alongside estradiol and estrone). It is the predominant estrogen during pregnancy and is known for its anti-proliferative properties.
Because estriol binds to estrogen receptors more weakly than estradiol, it provides therapeutic benefit to vaginal and urogenital tissues without strongly stimulating endometrial or breast tissue. This makes it a preferred option for:
- Vaginal estrogen therapy
- Women with a history of estrogen sensitivity
- Patients at risk for estrogen-dominant conditions
Clinical Applications
Estriol 30 gm Cream is commonly used for:
- Genitourinary Syndrome of Menopause (GSM)
- Vaginal atrophy and dryness
- Postmenopausal or surgical menopause support
- Vaginal irritation, itching, or recurrent infections
- Dyspareunia (painful intercourse)
- Postpartum tissue healing and hormonal balancing
- Adjunct to systemic HRT or in women contraindicated for systemic therapy
Patient Benefits
When used as prescribed, patients may experience:
- Improved vaginal hydration and comfort
- Enhanced elasticity and lubrication during intimacy
- Reduction in inflammation, redness, and tissue fragility
- Decreased frequency of vaginal infections and irritation
- Better urogenital health and overall well-being
Dosage and Use
- Initial phase: Apply daily for 2–4 weeks
- Maintenance: Reduce to 2–3 times per week
- Apply to vaginal mucosa or vulvar area as directed
- Delivered via syringe, applicator, or pump for measured doses
- Always follow prescribing physician’s instructions
Monitoring and Safety
Though topical estriol is minimally systemic, periodic evaluation is recommended, especially in long-term therapy. Providers may monitor:
- Estradiol/Estriol levels (if part of broader HRT)
- Pelvic exams and endometrial status
- Symptom changes or recurrence
- Any signs of systemic hormone effects
Side Effects
Estriol is generally well-tolerated, but side effects may include:
- Mild breast tenderness
- Local irritation or itching (transient)
- Vaginal discharge (typically resolves with use)
- Spotting or breakthrough bleeding (rare)
Discontinue and contact a provider if unusual symptoms persist.
Contraindications
- Known history of hormone-sensitive cancers
- Undiagnosed vaginal bleeding
- Active vaginal infections
- Known hypersensitivity to any component of the cream
- Pregnancy (unless used under specialist guidance)
Storage and Packaging
- Store at room temperature: 15–25°C (59–77°F)
- Avoid exposure to direct sunlight and moisture
- Supplied in 30 gm metered-dose airless pump or pharmacy-grade jar/syringe
- For external or intravaginal use only
Ideal Candidates
Estriol cream is particularly beneficial for:
- Women in early menopause or perimenopause
- Postmenopausal patients with vaginal symptoms only
- Women recovering from chemotherapy or surgical menopause
- Patients who cannot tolerate or do not require systemic HRT
- Those seeking a gentler, low-risk hormone option
Estriol 30 gm Cream provides an effective, well-tolerated solution for restoring feminine comfort and urogenital tissue health in women experiencing hormone-related dryness, discomfort, or atrophy. Its low-potency, bioidentical profile makes it a safe and practical choice for long-term relief under medical supervision.
